Micro to macro

Since the attack on nerve sites is fairly random, the loss of neurological functions as the nerves die can be very, very subtle indeed, almost impossible to catalog, assess, diagnose as pathology. Eventually, accumulations of scar in certain regions create deficits massive enough that they appear as changes in the macroscopic behavior of the organism, the human organism. Most frequently, changes in gait or sudden eyesight blurring appear first. Subtler symptoms tend to be misdiagnosed or missed entirely. Fatigue, a reaction of the organism to the decrease in total neural tissue in the brain, is the most common symptom, but is often mistaken for Epstein-Barr or chronic fatigue syndrome. As is depression. Knowing your brain is shrinking and dying.